Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D.Structure and mechanism of the mammalian fructose transporter GLUT5.Nature. 2015 Sep 30.
Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J. PPARβ/δ activation of CD300a controls intestinal immunity.Sci Rep.2014 Jun 24;4:5412.
Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. J Neuropathol Exp Neurol.2014 Jul;73(7):714-28.
Maejima T, Inoue T, Kanki Y, Kohro T, Li G, Ohta Y, Kimura H, Kobayashi M, Taguchi A, Tsutsumi S, Iwanari H, Yamamoto S, Aruga H, Dong S, Stevens JF, Poh HM, Yamamoto K, Kawamura T, Mimura I, Suehiro J, Sugiyama A, Kaneki K, Shibata H, Yoshinaka Y, Doi T, Asanuma A, Tanabe S, Tanaka T, Minami T, Hamakubo T, Sakai J, Nozaki N, Aburatani H, Nangaku M, Ruan X, Tanabe H, Ruan Y, Ihara S, Endo A, Kodama T, Wada Y. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.PLoS One.2014 May 5;9(5):e96005.
Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD. G protein-dependent basal and evoked endothelial cell vWF secretion.Blood. 2014 Jan 16;123(3):442-50.
Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T, Iwanari H, Ushio-Fukai M, Fukai T. Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury. Arterioscler Thromb Vasc Biol. 2013 Jan 24.
Daigo K, Hamakubo T. Host-protective effect of circulating pentraxin 3 (PTX3) and complex formation with neutrophil extracellular traps. Front Immunol. 2012;3:378.
Yumura K, Ui M, Doi H, Hamakubo T, Kodama T, Tsumoto K, Sugiyama A. Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin. Protein Sci. 2013 Feb;22(2):213-21.
Mochizuki Y, Ohashi R, Kawamura T, Iwanari H, Kodama T, Naito M, Hamakubo T. Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. J Biol Chem. 2013 Jan 11;288(2):1009-21.
Kusano-Arai O, Iwanari H, Mochizuki Y, Nakata H, Kodama T, Kitoh T, Hamakubo T. Evaluation of the asparagine synthetase level in leukemia cells by monoclonal antibodies. Hybridoma (Larchmt). 2012 Oct;31(5):325-32.
Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H, Yamamoto T. Inhibition of DNA Damage-induced Apoptosis through Cdc7-mediated Stabilization of Tob. J Biol Chem. 2012 Nov 23;287(48):40256-65.
Mitsui K, Sakihama T, Takahashi K, Masuda K, Fukuda R, Hamana H, Sato T, Hamakubo T. Functional reconstitution of olfactory receptor complex on baculovirus. Chem Senses. 2012 Nov;37(9):837-47.
Kudo S, Caaveiro JM, Miyafusa T, Goda S, Ishii K, Matsuura T, Sudou Y, Kodama T, Hamakubo T, Tsumoto K. Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. Mol Biosyst. 2012 Aug;8(8):2050-3.
Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro J, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y. Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A. Mol Cell Biol. 2012 Aug;32(15):3018-32.
Wada Y, Ohta Y, Xu M, Tsutsumi S, Minami T, Inoue K, Komura D, Kitakami J, Oshida N, Papantonis A, Izumi A, Kobayashi M, Meguro H, Kanki Y, Mimura I, Yamamoto K, Mataki C, Hamakubo T, Shirahige K, Aburatani H, Kimura H, Kodama T, Cook PR, Ihara S. A wave of nascent transcription on activated human genes.Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18357-61.
Saitoh R, Ohtomo T, Ito Y, Nezu J, Kimura N, Funahashi S, Aso Y, Ohizumi I, Kodama T, Hamakubo T, Tsuchiya M. Recovery of functional peptide transporter PepT1 in budded baculovirus fraction. Protein Expr Purif., Sep 26, 2005.
Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T. Gene expression profiling of potential peroxisome proliferators activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing PPAR isoform. Nucl Recept. Oct 3;3(1):3, 2005.
Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. Apr 1;19(7):815-26. 2005.
Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T. Association of active gamma -secretase complex with lipid rafts. J Lipid Res. May;46(5):904-12. 2005.
Watanabe Y, Jiang S, Takabe W, Ohashi R, Tanaka T, Uchiyama Y, Katsumi K, Iwanari H, Noguchi N, Naito M, Hamakubo T, Kodama T. Expression of the LXR{alpha} Protein in Human Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol. Mar;25(3):622-7. 2005.
Watanabe Y, Tanaka T, Uchiyama Y, Takeno T, Izumi A, Yamashita H, Kumakura J, Iwanari H, Shu-Ying J, Naito M, Mangelsdorf DJ, Hamakubo T, Kodama T. Establishment of a monoclonal antibody for human LXRalpha: Detection of LXRalpha protein expression in human macrophages.
Nucl Recept. May 9;1(1):1. 2003
Urano Y, Yamaguchi M, Fukuda R, Masuda K, Takahashi K, Uchiyama Y, Iwanari H, Jiang SY, Naito M, Kodama T, Hamakubo T. A novel method for viral display of ER membrane proteins on budded baculovirus.
Biochem Biophys Res Commun. 308(1):191-6. 2003
Huang Y, Uchiyama Y, Fujimura T, Kanamori H, Doi T, Takamizawa A, Hamakubo T, Kodama T. A human hepatoma cell line expressing hepatitis c virus nonstructural proteins tightly regulated by tetracycline. Biochem Biophys Res Commun. 2;281(3):732-40. 2001.
Umetani M, Mataki C, Minegishi N, Yamamoto M, Hamakubo T, Kodama T. Function of GATA transcription factors in induction of endothelial vascular cell adhesion molecule-1 by tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol. 21(6):917-22. 2001.
Saiura A, Mataki C, Murakami T, Umetani M, Wada Y, Kohro T, Aburatani H, Harihara Y, Hamakubo T, Yamaguchi T, Hasegawa G, Naito M, Makuuchi M, Kodama T. A comparison of gene expression in murine cardiac allografts and isografts by means DNA microarray analysis. Transplantation. Jul 27;72(2):320-9. 2001.
Takabe W, Kodama T, Hamakubo T, Tanaka K, Suzuki T, Aburatani H, Matsukawa N, Noguchi N. Anti-atherogenic antioxidants regulate the expression and function of proteasome {alpha}-type subunits in human endothelial cells. J Biol Chem. 276(44), 40497-501, 2001.
Kohro T. Nakajima T. Wada Y. Sugiyama A. Ishii M. Tsutsumi S. Aburatani H. Imoto I. Inazawa J. Hamakubo T. Kodama T. and Emi M. Genomic Structure and Mapping of Human Orphan Receptor LXR Alpha: Upreglation of LXRa mRNA During Monocyte to Macrophage Differentiation. Journal of Atherosclerosis and Thrombosis, 7(3), 145-151. 2000.
Morikawa S. Umetani M. Nakagawa S. Yamazaki H. Suganami H. Inoue K. Kitahara M. Hamakubo T., Kodama T. and Saito Y. Relative Induction of mRNA for HMG CoA Reductase and LDL Receptor by five Different HMG CoA Reductase Inhibitors in Cultured Human Cells. Journal of Atherosclerosis and Thrombosis, 7(3), 138-144. 2000
Mataki C. Murakami T. Umetani M. Wada Y. Ishii M. Tsutsumi S. Aburatani H. Hamakubo T. and Kodama T. A Novel Zinc Finger Protein mRNA in Human Umbilical Vein Endothelial Cells is Profoundly Induced by Tumor Necrosis Factor a. Journal of Atherosclerosis and Thrombosis, 7(2), 97-103. 2000.
Murakami T. Mataki C. Nagao C. Umetani M. Wada Y. Ishii M. Tsutsumi S. Kohro T. Saiura A. Aburatani H. Hamakubo T. and Kodama T. The Gene Expression Profile of Human Umbilical Vein Endothelial Cells Stimulated by Tumor Necrosis Factor Using DNA Microarray Analysis. Journal of Atherosclerosis and Thrombosis, 7(1), 39-44. 2000.
Nakajima T, Iwaki K, Hamakubo T, Kodama T, Emi M: Genomic structure of the gene encoding human 3-hydroxy-3-methyl-glutaryl coenzyme A reductase: comparison of exon/intron organization of sterol-sensing domains among four related genes. J Hum Genet, 45(5):284-9. 2000.
Umetani M, Nakao H, Doi T, Iwasaki A, Ohtaka M, Nagoya T, Mataki C, Hamakubo T, Kodama T. A Novel Cell Adhesion Inhibitor, K-7174, Reduces the Endothelial VCAM-1 Induction by Inflammatory Cytokines, Acting through the Regulation of GATA. Biochem Biophys Res Commun. Jun 7;272(2):370-374. 2000.
Shirai H, Murakami T, Yamada Y, Doi T, Hamakubo T, Kodama Structure and function of type I and II macrophage scavenger receptors. TMech Ageing Dev 1999 ;111:107-21
Heigoro Shirai, Mineko Yamaguchi, Ryuichiro Sato, Yoshiki Kawabe, Rie Fukuda, Tatsuhiko Kodama and Takao Hamakubo,. Degradation Enzymes for Sterol Regulatory element Binding Protein; Common Diseases:Genetic and Pathogenic Aspects of Multifunction Diseases (1999),pp131-138. Elsevier Science
Nakajima T., Hamakubo T., Kodama T., Inazawa J., and M. Emi. : Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene. J Hum Genet , 44, pp 402 – 7, 1999.
Takaku M, Wada Y, Jinnouchi K, Takeya M, Takahashi K, Usuda H, Naito M, Kurihara H, Yazaki Y, Kumazawa Y, Okimoto Y, Umetani M, Noguchi N, Niki E, Hamakubo T,Kodama T.An In vitro coculture model of transmigrant monocytes and foam cell formation.Arterioscler Thromb Vasc Biol Oct;19(10):2330-9, 1999.
Yamaguchi, M., Shirai, H., Sato, R., Kawabe,Y., Fukuda, R., Kodama, T., and Hamakubo, T. Characterization of cleaving enzymes for sterol regulatory element binding protein in hamster liver microsomes. Biochem Biophys Res Commun. 258, 542-7, 1999.
Kawabe Y., Suzuki T., Hayashi M., Hamakubo T., Sato R., Kodama T.: The physiological role of sterol regulatory element-binding protein-2 in cultured human cells. Biochimica et Biophysica Acta, 1436, pp307-318, 1999.
Yamada Y, Doi T., Hamakubo T. and T. Kodama:”Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system. Cellular and Molecular Life Sciences, 54, pp628-640, 1998
Mosqueda-Garcia, R., Appalsamy M, Fernandez-Violante, R., Hamakubo, T., and R. Stainback. “Modulatory Effects of Endothelin on Baroreflex Activation in the Nucleus of the Solitary Tract” Europian Journal of Pharmacology, 351, pp203-207, 1998
Yasukiyo Mori, Hiroaki Matsubara, Satoshi Murasawa, Kazuhisa Kijima, Katsuya, Maruyama, Hiroyasu Tsukaguchi, Naohiko Okubo, Takao Hamakubo, Tadashi Inagami, Toshiji Iwasaka, Mitsuo Inada.: “Translational Regulation of Angiotensin II Type 1A Receptor Role of Upstream AUG Triplets” Hypertension, 28 : 810-817 ,1996
Mosqueda-Garcia, R., Fernandez-Violante, R., Hamakubo, T., and R. Stainback. “Vasopressin mediates the pressor effects of endothelin in the subfornical organ of the rat” Journal of Pharmacology & Experimental Therapeutics, 277(2):1034-1-42, 1996.
Mosqueda-Garcia, R., Stainback, R., Fernandez-Violante, R., and T. Hamakubo “Cardiovascular effects of endothelin in brain nuclei regulating vasopressin release.” J Cardiovasc. Pharmacol., 26(suppl 3): S159-S162, 1995.
Kenji Ohyama, Yamano, Y., Sano, T., Nakagomi, Y., Hamakubo, T., Morishima, I., and T. Inagami:”Disulfide bridges in extracellular domains of angiotensin II receptor type IA” Regulatory Peptides, 57. 141-147. 1995.
Yamano, Y., Ohyama, K., Kikyo, M., Sano, T., Nakagomi, Y., Inoue, Y., Nakamura, I., Guo, D-F., Hamakubo, T., and T. Inagami.:”Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1).” Journal of Biological Chemistry, 270. pp14024-14030. 1995.
Yoshida, M., Hamakubo, T., and T. Inagami.;Angiotensin II-mediated Pressor Effect of Rat Joining Peptide. American Journal of Physiology (Regulatory Integrative Comperative Physiology. 35), 266, R802-R808. 1994
Kambayashi, Y., Bardhan, S., Takahashi, K., Tsuzuki, S., Inui, H., Hamakubo, T., and T. Inagami.;Molecular Cloning of a Novel Angiotensin II Receptor Isoform Involved in Phosphotyrosine Phosphatase Inhibition. Journal of Biological Chemistry, 268; 24543-24546, 1993
Hamakubo, T., Yoshida, M., Nakajima, K., Watanabe, T. X., Mosqueda-Garcia, and T. Inagami. Central Cardiovascular Effects of Joining Peptide in the Genetically Hypertensive Rat. American Journal of Physiology (Regulatory Integrative Comperative Physiology, 34), 265; R1184-R1190, 1993
Hamakubo, T., Furuta, H., Ichimura, M., Appalsamy, M., Mosqueda-Garcia, R., Robertson, D. and T. Inagami.;A Na Pump Inhibitor from Bovine Posterior Pituitary: Purification, Structure Determination and Its Cardiovascular effect in rat. Biochemical and Biophysical Research Communications, 189, 691-696; 1992
Shimizu, K., Hamamoto, T., Hamakubo, T., Lee, W. J., Suzuki, K., Nakagawa, Y., Murachi T., and T. Yamamuro.;Immunohistochemical and Biochemical Demonstration of Calcium-Dependent Cystein Proteinase (Calpain) in Calcifying Cartilage of Rats. Journal of Orthopaedic Research, 9; 26-36, 1991
Suzuki, K., Shimizu, K., Hamamoto, T., Nakagawa, Y., Hamakubo, T. and T. Yamamuro. Biochemical Demonstration of Calpains and Calpastatin in Osteoarthritic Synovial Fluid. Arthritis and Rheumatism, 33; 728-732, 1990
Kinoshita, M., Hamakubo, T., Fukui, I., Murachi, T., and H. Toyohara.;Significant Amount of Multicatalytic Proteinase Identified on Membrane from Human Erythrocyte. Journal of Biochemistry, 107; 440-444, 1990
Hamakubo, T., Ueda, M., Takano, E., and T. Murachi.;Distributional and Developmental Variations of Multiple Forms of Calpastatin in Mouse Brain. Journal of Enzyme Inhibition, 3; 203-210, 1990
Takano, E., Hamakubo, T., Kawatani, Y., Ueda, M., Kannagi, R., and T. Murachi. Multiple Forms of Calpastatin in Pig Brain. Biochemistry International, 19; 633-643. 1989
Murachi, T., Murakami, T., Ueda, M., Fukui, I., Hamakubo, T., Adachi, Y., and M. Hatanaka.; “The Calpain-Calpastatin System in Hematopoietic Cells” in CalciumProtein Signaling. (Hidaka, H., Carafoli, E., Means, A. R., and T. Tanaka, eds.), pp445-454. Plenum Publishing Corporation 1989
Ogata, N., Yonekawa, Y., Taki, W., Kannagi, R., Murachi, T., Hamakubo, T., and H. Kikuchi. Degradation of Neurofilament Protein in Cerebral Ischemia. Journal of Neurosurgery, 70; 103-107, 1989
Murakami, T., Ueda, M., Hamakubo, T., and T. Murachi.;;Identification of Both Calpains I and II in Nucleated Chicken Erythrocytes. Journal of Biochemistry, 103; 168-171, 1988
Fukui, I., Toyohara, H., Ito, K., Hamakubo, T., and T. Murachi.;Molecular and Catalytic Characterization of Intact Heterodimeric and Derived Monomeric Calpains Isolated under Different Conditions from Pig Polymorphonuclear Leukocytes. Biochemistry, 27; 3260-3267, 1988
Murachi, T., Hatanaka, M., and T. Hamakubo. Calpains and Neuropeptide Metabolism. in Neuropeptides and Their Peptidases. (Turner, A. J., ed.), pp202-228.Ellis-Horwood, London. 1987
Hamakubo, T., Ueda, M., Fucharoen, S., Wilairat, P., Pimainork, Y., and T. Murachi. Thalassemic Red Blood Cells and the Study of Membrane Protein. Contemporary Themes in Biochemistry, ICSU Short Reports, 6; 524-525, 1986
Hamakubo, T., Kannagi, R., Murachi, T., and A. Matus.; Distribution of Calpain in Rat Brain. Journal of Neuroscience, 6; 3103-3111, 1986
Miyachi, Y., Yoshimura, N., Suzuki, S., Hamakubo, T., Kannagi, R., Imamura, S., and T. Murachi.;Biochemical Demonstration and Immunohistochemical Localization of Calpain in Human Skin. Journal of Investigative Dermatology, 86; 346-349, 1986
Yoshimura, N., Ohtuki, H., Hamakubo, T., Kitahara, A., Kannagi, R., and T. Murachi.;Distribution of Calpain in Various Organs of Rat: An Immunohistochemical Study. Biomedical Research, 5; 419-425, 1984